Variability of bioavailability and intestinal absorption mechanism of mizoribine and bisoprolol

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590181
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: University of Toyama
• Principal Investigator: HASHIMOTO Yukiya 富山大学, 大学院医学薬学研究部(薬学), 教授 (90228429)
• Co-Investigator(Kenkyū-buntansha): NOZAWA Takashi 富山大学, 大学院医学薬学研究部(医学), 准教授 (00180737) ; ISHIDA Kazuya 富山大学, 大学院医学薬学研究部(薬学), 助教 (90550509)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: バイオアベイラビリオティ

Outline of Final Research Achievements

The large variability of bioavailability (F) of drugs induces the positive correlation between oral clearance (CL/F) and apparent volume of distribution (V/F). In the present study, we performed the clinical pharmacokinetic trials of mizoribine and bisoprolol. The population pharmacokinetic analysis was performed by use of the nonlinear mixed effects model (NONMEM) program. As the results, we observed the positive correlation between CL/F and V/F of mizoribine in pediatric patients of renal transplantation, indicating large variability of F of the drug. In addition, we observed the positive correlation between CL/F and V/F of bisoprolol in Japanese patients with cardiovascular diseases, indicating large variability of F of the drug.

Free Research Field

薬物動態学