Evaluation of focal availabilities of drugs by monitoring of dynamic diffusion and clearance processes of unbound drug concentrations

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590193
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Okayama University
• Principal Investigator: KUROSAKI Yuji 岡山大学, 医歯(薬)学総合研究科, 教授 (90161786)
• Co-Investigator(Renkei-kenkyūsha): KAWASAKI Hiromu 松山大学, 薬学部, 教授 (60125151) ; AIBA Tetsuya 岡山大学, 大学院医歯薬学総合研究科, 准教授 (00231754)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 局所薬物動態 / 局所利用率 / ドドラッグデリバリーシステム / マイクロダイアリシス / 微小透析 / ファーマコキネティクス / 拡散モデル

Outline of Final Research Achievements

To realize a well-controlled regionally confined drug action, a new scientific platform that covers topical bioavailability and topical pharmacokinetics has been required. In this study, lateral diffusion and systemic clearance processes of drugs applied to the abdominal muscle of the rat was monitored by microdialysis (MD) and a new concept, focal bioavailability, based on unbound drug concentration profiles in specific site is evaluated with its pharmacokinetic model.

Free Research Field

製剤設計評価学