2014 Fiscal Year Final Research Report
Genetic polymorphisms in FADS1 and FADS2 alter desaturase activity in a Japanese population
| Project/Area Number |
24590204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences (2013-2014)
Chiba Institute of Science (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UCHIYAMA Kan 東京慈恵会医科大学, 医学部, 講師 (10385297)
ODAHARA Shun-ichi 東京慈恵会医科大学, 医学部, 助教 (50445673)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | Δ6 desaturase / IBD / Crohn's disease / n-3 PUFA / n-6 PUFA / genetic polymorphism / arachidonate cascade / Japanese |
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| Outline of Final Research Achievements |
We have studied the genetic analysis of the Δ6 desaturase (FADS2) polymorphisms, alter desaturase activity in Japanese individuals, on the metabolic activity of 3-/6-polyunsaturated fatty acid (PUFA).
In addition, we are comparing the relationship between the dietary PUFA ratio and genetic polymorphisms using an in vivo evaluation method in 53 Inflammatory Bowel Disease Japanese patients.
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| Free Research Field |
医歯薬学
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