2014 Fiscal Year Final Research Report
Role of drug metabolizing enzymes in acquired resistance of breast cancer cells to anticancer drugs
| Project/Area Number |
24590217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 薬物代謝酵素 / 乳癌 / 耐性化 / グルクロン酸抱合 / タモキシフェン / MCF-7 |
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| Outline of Final Research Achievements |
In this study, to clarify the generation mechanism of breast cancer cells resistant to anti-breast cancer drug tamoxifen (TAM), and was intended to be the beginning of the resistance overcome. When a drug-metabolizing enzyme UGT1A4 that inactivates TAM in breast cancer cells was overexpressed, it was revealed that the intracellular concentrations of TAM is reduced by excretion as an inactive form via transporter MRP-1. Furthermore, unlike mechanism TAM resistance of the that have been reported so far in TAM resistant strain, that overexpression of the drug-metabolizing enzyme can be one of TAM resistance mechanism of breast cancer was suggested.
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| Free Research Field |
薬物代謝・毒性学
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