2014 Fiscal Year Final Research Report
Functions of the non-clustered protocadherins in the neurogenesis and organogenesis
Project/Area Number |
24590231
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | Gunma University |
Principal Investigator |
MURAKAMI Tohru 群馬大学, 医学(系)研究科(研究院), 准教授 (10239494)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 発生学・形態形成学 / 発生生物学 / 細胞接着因子 / プロトカドヘリン / ゼブラフィッシュ / in situハイブリダイゼーション / ドミナントネガティブ変異体 / アンチセンスMorpholino |
Outline of Final Research Achievements |
The expression and functional analyses of a protocadherin Pcdh10a in zebrafish embryos indicated that it is expressed in the lens primordium and plays a significant role in its development. Comparative evidences is not known in its isoform Pcdh10b, and in other cell-adhesion molecules in other species. This diversity was phylogenetically hypothesized to have been introduced to zebrafish by the third-round whole genome duplication specific to the teleosts. Three-dimensional analysis technology is being developed for further analysis in larva and adult fish.
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Free Research Field |
解剖学、発生学、発生生物学
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