Functions of the non-clustered protocadherins in the neurogenesis and organogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590231
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Gunma University
• Principal Investigator: MURAKAMI Tohru 群馬大学, 医学(系)研究科(研究院), 准教授 (10239494)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 発生学・形態形成学 / 発生生物学 / 細胞接着因子 / プロトカドヘリン / ゼブラフィッシュ / in situハイブリダイゼーション / ドミナントネガティブ変異体 / アンチセンスMorpholino

Outline of Final Research Achievements

The expression and functional analyses of a protocadherin Pcdh10a in zebrafish embryos indicated that it is expressed in the lens primordium and plays a significant role in its development. Comparative evidences is not known in its isoform Pcdh10b, and in other cell-adhesion molecules in other species. This diversity was phylogenetically hypothesized to have been introduced to zebrafish by the third-round whole genome duplication specific to the teleosts. Three-dimensional analysis technology is being developed for further analysis in larva and adult fish.

Free Research Field

解剖学、発生学、発生生物学