APC protein's novel function related to morphogenesis and cell differentiation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590234
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Gifu University
• Principal Investigator: SENDA TAKAO 岐阜大学, 医学(系)研究科(研究院), 教授 (10187875)
• Co-Investigator(Kenkyū-buntansha): AZUMA Kagaku 岐阜大学, 大学院医学系研究科, 講師 (20273146)
• Research Collaborator: WANG Tuya 岐阜大学, 大学院医学系研究科
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: APC / APC1638T / 腸上皮 / 細胞動態 / 骨格 / 歩行異常 / hair cycle

Outline of Final Research Achievements

APC (adenomatous polyposis coli) was originally identified as a tumor suppressor protein. In the present study, we investigated phenotypes of the APC1638T mouse, which lacks the C-terminus of APC but retains β-catenin-binding domain thus being free of tumors. Various phenotypes of the APC1638T mouse were revealed. Both length of the small intestine and that from the bottom of an intestinal crypt and the tip of a villus in the APC1638T mouse are longer than that in wild-type one. Velocity of the intestinal epithelial cell movement along the villus in the APC1638T mouse is faster than that in wild-type one. Also, the APC1638T mouse exhibited skeletal disorders (short limbs, kyphosis and mal-calcification), lacking of limb-cooperation in gait, and hair-cycle irregularities.

Free Research Field

発生学