The clustering mechanism and the driving force of the macro membrane domains

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590264
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Fujita Health University
• Principal Investigator: NOMURA Ryuji 藤田保健衛生大学, 医学部, 講師 (20325161)
• Co-Investigator(Kenkyū-buntansha): SHIMOMURA Atsushi 北海道医療大学, 心理科学部, 教授 (50340237) ; KOGO Akiko 群馬大学, 医学系研究科, 助教 (20340242)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アクチンフィラメント / CD13 / 膜ドメイン / コロナウイルス

Outline of Final Research Achievements

The virus entry has two types of the entry routes; one is a route from the binding-site of the virus on the plasma membrane, while the other is a moving on the plasma membrane from binding-site to entry site. We revealed that human coronavirus 229E uses the later route and that the virus needs the macro clustering of membrane domains. Here, we studied the movement of the cross-linked virus receptors by antibodies in order to clarify the mechanism of the virus movement on the plasma membrane. The results suggest that the macro clustering of membrane domains depends on the movement of the membrane-associated actin filaments.

Free Research Field

解剖学・細胞生物学