Inhibitory mechanism of quercetin on ENaC in salt-sensitive hypertension

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590283
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: NIISATO Naomi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00237645)
• Co-Investigator(Kenkyū-buntansha): MARUNAKA Yoshinori 京都府立医科大学, 大学院医学研究科, 教授 (00127036) ; MIYAZAKI Hiroaki 京都府立医科大学, 大学院医学研究科, 講師 (30360027) ; NAKAJIMA Kenichi 京都府立医科大学, 大学院医学研究科, 助教 (40398392) ; HOSOGI Shigekuni 京都府立医科大学, 大学院医学研究科, 客員講師 (30433254) ; YOKOYAMA Noriko 京都府立医科大学, 医学部, 博士研究員 (40112958)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: フラボノイド / ENaC / Na+再吸収 / ケルセチン

Outline of Final Research Achievements

In our previous studies, we have revealed that chronic treatment with quercetin decreased epithelial Na+ channel (ENaC)-mediated Na+ reabsorption by suppressing ENaC gene expression. In this study, we investigated the acute effect of quercetin on ENaC-mediated Na+ reabsorption and found that application of quercetin rapidly reduced ENaC-mediated Na+ reabsorption by inhibiting the protease-dependent ENaC activity and Na+, K+ ATPase activity in renal epithelial A6 cells.

Free Research Field

細胞生理学、細胞生物学