2014 Fiscal Year Final Research Report
Enriched environment on stress-induced abnormal behaviors
| Project/Area Number |
24590304
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | Meijo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 飼育環境 / 精神疾患 / 疾患予防 |
|---|
| Outline of Final Research Achievements |
The purpose of this study was to clarify the endogenous system to protect the psychiatric disease. Firstly, DNA array showed more than 100 molecules expressed highly in the mouse brain by environmental enrichment for 4 weeks. One of them, dynorphin A, an endogenous opioid peptide, increased by the running wheel in the brain. Additionally, dynorphin A (1-13), a potent fragment of this peptide prevented repeated stress-induced behavioral impairments in mice. These results suggest that dynorphin might be induced to express in the brain by enriched environment and might alleviate the stress-induced behavioral impairments.
|
| Free Research Field |
神経精神薬理学
|
