Involvement of prostaglandins in cognitive function induced by brain inflammation

2015 Fiscal Year Final Research Report

• Project/Area Number: 24590314
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Institute for Developmental Research, Aichi Human Service Center
• Principal Investigator: MAKOTO MIZUNO 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (20345515)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 脳内炎症 / 行動解析 / 発達障害

Outline of Final Research Achievements

Inflammatory process is implicated in various cognitive disorders. In this experiments, we examine prostaglandin induced during development, which are involved in cognitive functions in mice. We use lipopolysaccharide (LPS) for induction of prostaglandins. Prenatal maternal LPS exposure leads to behavioral deficits such as cognitive disorder and social disability in the offspring. After birth inhibition of prostaglandin EP2 receptor show still behavioral deficits. However, at the same time for LPS injection, inhibition of prostaglandin EP2 receptor show amelioration of behavioral abnormalities. Taken together, these results suggest that prostaglandin via prenatal brain inflammation leads to behavioral deficits in the offspring.

Free Research Field

薬理