Suppressive role of histamine in hepatic colorectal cancer matastasis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590322
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Yamaguchi University
• Principal Investigator: KURAMASU Atsuo 山口大学, 医学(系)研究科(研究院), 准教授 (90302091)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Kiyoshi 国立研究開発法人国立がん研究センター, 先端医療開発センター, 分野長 (30346564) ; TAMADA Koji 山口大学, 大学院医学系研究科, 教授 (00615841)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ヒスタミン / 大腸癌 / 肝転移 / 制御性T細胞

Outline of Final Research Achievements

Role of histamine in hepatic colorectal cancer matastasis was investigated using mice deficient of endogenous histamine. In mouse hepatic colorectal cancer matastasis model, mice lacking histamine-synthesizing enzyme showed significantly shorter survival, suggesting that histamine had suppressive role in hepatic metastatis. In spleen and liver from histamine-deficient mice with hepatic metastasis, regulatory T cells were significantly increased, showing a possible mechanism of Treg-mediated suppression of anti-tumor immune response.

Free Research Field

薬理学