Roles of cell adhesion molecules in enhanced cell motility induced by hypoxia-inducible factor HIF

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590364
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Aichi Medical University
• Principal Investigator: KANNAGI Reiji 愛知医科大学, 公私立大学の部局等, 客員教授 (80161389)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 生体分子医学 / 低酸素誘導因子

Outline of Final Research Achievements

Cellular hypoxia remarkably enhances cellular mobility. In the previous project we had found alterations in the expression of various cell adhesion molecules. In the current project we intended to identify which adhesion molecule among them is mainly responsible for the enhancement of cellular mobility induced by hypoxia. Our results indicated that the changes occurred in the CD44-hyaluronan cell adhesion system, especially altered transcription levels of the genes involved in the synthesis and catabolism of hyaluronan induced by hypoxia-inducible factor (HIF), are mainly responsible for the enhanced cellular motility under hypoxia.

Free Research Field

医歯薬学