2014 Fiscal Year Final Research Report
Role of a novel lysophospholipase in phospholipid metabolism
| Project/Area Number |
24590367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
HIRABAYASHI Tetsuya 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (90345025)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ホスホリパーゼ / コリン / グリセロホスホコリン / 肝臓 / 脂肪組織 / 脂質代謝 / 褐色化 |
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| Outline of Final Research Achievements |
We have discovered that a novel lysophospholipase, iPLA2θ, is essential for the mobilization of free choline from the major membrane phospholipid, phoshatidylcholine. Mice deficient in this enzyme cannot utilize sufficient endogenous free choline in the liver, which leads to a shortage of hepatic methyl donors, betaine and S-adenosylmethionine. Our results also indicate that iPLA2θ is required for normal lipid and glucose metabolism.
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| Free Research Field |
脂質生物学
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