Role of inflammation and phospholipase Cepsilon in tumor development

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590379
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kobe University
• Principal Investigator: EDAMATSU Hironori 神戸大学, 医学(系)研究科(研究院), 助教 (70335438)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Rasシグナル / 炎症 / 腫瘍微小環境 / 糖代謝 / 亜鉛

Outline of Final Research Achievements

Tumor development is driven not only by the alterations in the genome of cancer cells itself but also by the surrounding microenvironment that supplies factors crucial for their growth and survival. Although it is known that phospholipase Cε (PLCε), an effector of Ras and Rap small GTPases, plays an important role in tumor development through augmenting cancer-associated inflammation in the tumor microenvironment, the molecular mechanism by which PLCε-mediated tumor development is not fully understood. This research shows that PLCε mediates signals that upregulates proinflammatory gene transcription through prolongation of IκB inactivation. It shows that the survival of cells overexpressing the mutationally-activated H-Ras in vitro is affected by the supply of zinc ions and glucose, both of which are known to be supplied from the microenvironment in vivo.

Free Research Field

医歯薬学