The double regulation of intestinal immunity and its implications in inflammatory bowel disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590380
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kobe University
• Principal Investigator: OKAZAWA HIDEKI 神戸大学, 医学(系)研究科(研究院), 医学研究員 (80334126)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: シグナル伝達 / 生体分子 / 癌 / 炎症 / 免疫学

Outline of Final Research Achievements

Intestinal epithelial cells and immune cells are known to regulate intestinal immunity, it remains unclear how these cells regulate intestinal immunity, however. We examined the double regulatory role of intestinal immunity by epithelial and immune cells, focusing on SAP-1/pp90 and CD47-SIRPα signaling systems which we have originally identified. We found that phosphorylated pp90 regulates chemokine production from epithelial cells. Moreover, we demonstrated that SIRPα expression intrinsic to dendritic cells is essential for homeostasis of dendritic cells. Our findings suggest that both SAP-1/pp90 and CD47-SIRPα signaling systems regulate intestinal immunity and their disruption is implicated in the development of inflammatory bowel disease.

Free Research Field

病態医化学