A novel mechanism of breast carcinogenesis caused by transcription-coupled DNA damage

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590388
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Aichi Cancer Center Research Institute (2014); Kumamoto University (2012-2013)
• Principal Investigator: KUWAHARA Kazuhiko 愛知県がんセンター(研究所), 腫瘍免疫学部, 室長 (10263469)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 非遺伝性散発性乳癌 / DNA傷害

Outline of Final Research Achievements

The occurrence of sporadic breast cancers is involved in long-term exposure of estrogen, which induces DNA damages in the epithelial cells of mammary glands. Estrogen stimulation induced rigorous DNA damages in ganp-depleted MCF7, suggesting that these damages is asoociated with abnormal development of mammary glands in mammary-specific ganp-deficient mice. GANP may be a tumor suppressive factor in mammary gland epithelia. Accordingly, it has been proved that low expression of GANP is an indicator of poor patients' prognosis in sporadic breast cancers.

Free Research Field

病態医化学