2014 Fiscal Year Final Research Report
Functional analysis of Fanconi anemia proteins in chromosome fragile site
| Project/Area Number |
24590391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YANAGI Shigeru 東京薬科大学, 生命科学部, 教授 (60252003)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | DNA複製 / ファンコニ貧血 |
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| Outline of Final Research Achievements |
We identified several genes that are involved in DNA replication stress response by siRNA library screening. These genes are reported to function as chromatin remodeling factors, but their roles in replication stress response are not clear. One of them is FancD2 related protein (D2RP) which interacts with FANCD2. According to the functional analysis, we identified that D2RP involved in DNA damage response. However, D2RP dose not take a role in FancD2 localization following DNA replication stress.
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| Free Research Field |
DNA損傷修復
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