The mechanisms of quinolinic acid-induced infiltration of reactive astrocytes and the amyloid beta peptide production in the activated glial cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590397
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: TAKIKAWA Osamu 独立行政法人国立長寿医療研究センター, 治療薬探索研究部, 室長 (70163342)
• Co-Investigator(Kenkyū-buntansha): OKUNO Alato 独立行政法人国立長寿医療研究センター, 長寿医療研究センター・ラジオアイソトープ管理室, 特任研究員 (50623980)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アルツハイマー病 / トリプトファン代謝 / アミロイドβペプチド / キノリン酸 / 神経毒 / IDO

Outline of Final Research Achievements

Alzheimer's disease (AD) is an increasing neurodegenerative disease and prevention and treatment of AD is an urgent social issue. Amyloid β peptide (Aβ) deposition is a well-known pathological feature in AD brains. A neurotoxin quinolinic acid (QA) has recently been to be involved in the AD pathology. In this study, the putative mediators responsible for QA-induced infiltration of reactive astrocytes in the AD brains have been tried to be identified and the molecular mechanism of the high Aβ production in reactive astrocytes was clarified.

Free Research Field

医歯薬学