Molecular Pathology of Mediastinal Lymphoproliferative Disoders of the Adult

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590422
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Nagoya City University
• Principal Investigator: INAGAKI Hiroshi 名古屋市立大学, 医学(系)研究科(研究院), 教授 (30232507)
• Co-Investigator(Kenkyū-buntansha): YAMADA Seiji 名古屋市立大学, 大学院医学研究科, 助教 (00566870) ; MASAKI Ayako 名古屋市立大学, 大学院医学研究科, 助教 (40648044)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 悪性リンパ腫 / 成人 / 縦隔 / 分子病理学

Outline of Final Research Achievements

Molecular pathological studies were was performed for adult mediastinal lymphoproliferative disorders in the Asia. In thymic MALT lymphoma, a frequent gene methylation was detected. In particular, p14 (ARF) gene methylation was associated with a larger tumor size, suggesting a role in tumor progression. In primary mediastinal large B-cell lymphoma, frequent abnormalities of CIITA and PDE5A genes have been reported from Western countries. We studied these abnormalities using FISH technique, although no significant abnormalities were found. This may suggest genetic difference between the Western and Asian cases. Progress of thymic MALT lymphoma in these 20 years was studied. After a critical discussion with distinguished hematopathologists, I published the results as the first author in the 4th WHO classification of thymic tumors.

Free Research Field

分子病理学