2015 Fiscal Year Final Research Report
Role of NKG2D ligands in prediction of response to cancer antibody therapy
| Project/Area Number |
24590441
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HATANAKA Yutaka 北海道大学, 北海道大学病院, 特任講師 (30589924)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | NKG2Dリガンド / 分子標的治療 |
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| Outline of Final Research Achievements |
In this study, we analyzed the protein expression profile of NKG2DL in breast cancer and malignant lymphoma, and examined the relationship with clinicopathological factors and patient survival to estimate an impact of NKG2DL modulation in antibody therapies. We showed that the clinicopathological significance of NKG2DL was different depending on molecular subtypes in breast cancer. Moreover, it was suggested that the significance of NKG2DL in rituximab-treated DLBCL might depend on cancer immunoresponse or cellular stress.
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| Free Research Field |
医歯薬学
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