Establishment of early diagnosis of pabcreatobiliary neoplasm

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590447
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kagoshima University
• Principal Investigator: HIGASHI Michiyo 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (60315405)
• Co-Investigator(Kenkyū-buntansha): YONEZAWA Suguru 鹿児島大学, 大学院医歯学総合研究科, 教授 (10175002) ; YOKOYAMA Seiya 鹿児島大学, 大学院医歯学総合研究科, 助教 (20569941)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 病理学 / 膵胆道腫瘍 / ムチン抗原 / MUC1 / MUC4 / MUC16 / 早期診断

Outline of Final Research Achievements

We had reported that expression profiles of mucins are closely associated with biological behavior of human pancreatobiliary neoplasms. We tried to analyse of clinical human samples, especially pancreatic juices used by a new method, MSE (methylation specific analysis) developed by us. This new tool has a potential for the application to possibility of distinguishing tumor between the pancreatic tumors with better prognosis or worse prognosis. In addition, we have found that expression profiles of mucin in EUS-FNA specimens are associated with biological behavior. Thus, analyses of mucin expression in pancreatic juice or EUS-FNA specimens are useful for pathological diagnosis and/or patients' treatment.

Free Research Field

医歯薬学