Regulation of vascular smooth muscle phenotypes by lysophosphatidic acid receptor signaling

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590462
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kurume University (2014); University of the Ryukyus (2012-2013)
• Principal Investigator: KATO Seiya 久留米大学, 医学部, 非常勤講師 (60268844)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 血管平滑筋細胞 / 形質転換 / 動脈硬化 / リゾフォスファチジン酸

Outline of Final Research Achievements

Lysophosphatidic acid (LPA) is a promoting factor of various aspects of phenotypic modulation of vascular smooth muscle cells, which has been known to be synthesized in the atheromatous lesions from oxidized low-density lipoprotein. Present study may suggest that the expression levels of non-EDG (endothelial differentiation gene) family receptors (LPA4-6) are relatively larger than those of EDG family receptors (LPA1-3). At the down-stream of non-EDG family receptors, differential manner in the activation of transcriptional factors from EDG family receptor activations, may contribute to the regulation of vascular smooth muscle functions.

Free Research Field

病理学