The immunological analysis of MARCH I regulating IgE production

2015 Fiscal Year Final Research Report

• Project/Area Number: 24590466
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Gihu University of Medical Science (2013-2015); The Institute of Physical and Chemical Research (2012)
• Principal Investigator: HOSHINO Mari (大村真理) 岐阜医療科学大学, 保健科学部, 教授 (10313511)
• Research Collaborator: HOSHINO Katsuaki 香川大学, 医学部, 教授 (50324843)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: E3ユビキチンリガーゼ

Outline of Final Research Achievements

Membrane-associated RING-CH I (MARCH-I) has been suggested as a E3 ubiquitin ligase for the regulation of immune system.
In this study we observed lower antigen(Ag)-specific antibody responses, especially and drastically lower Ag-specific IgE responses and lower Ag-specific T cell responses when MARCH I deficient mice were systemically immunized, compared with control mice. Next, we showed that MARCH I deficiency in dendritic cells was important for the decrease of immune responses such as low IgE production. This study revealed that MARCH I might be responsible for susceptibility to infection.

Free Research Field

免疫学、微生物学