2015 Fiscal Year Final Research Report
Analyses of enteric bacterial products as a causative agent for the onset of intestinal amoebiasis
| Project/Area Number |
24590511
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 赤痢アメーバ / Bacteroides fragilis / 腸持続感染 / GalGalNAcレクチン / ペルオキシダーゼ |
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| Outline of Final Research Achievements |
Promoting effects for the growth of Entamoeba histolytica, and for both persistent infections of E. histolytica and Tritrichomonas foetus to the cecum of CBA mouse were found in the culture supernatant of obligate anaerobic Bacteroides fragilis. Increase of corresponding sugar chains for GalGalNAc lectin of E. histolytica and inhibition of peroxidase activity were found by analyses of the culture supernatant. These bacterial metabolites have a possibility to affect to the onset of amoebiasis that has various conditions from latent to fulminant type.
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| Free Research Field |
寄生虫学; 腸管寄生原虫の培養
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