Analysis of the networks of the two-component sensor proteins in Streptococcus pyogenes

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590531
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including Mycology)
• Research Institution: Nagoya City University
• Principal Investigator: HASEGAWA Tadao 名古屋市立大学, 医学(系)研究科(研究院), 教授 (10314014)
• Co-Investigator(Kenkyū-buntansha): TATSUNO Ichiro 名古屋市立大学, 大学院医学研究科, 講師 (50311642) ; ISAKA Masanori 名古屋市立大学, 大学院医学研究科, 助教 (40336673)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: A群レンサ球菌 / 二成分制御系因子 / 環境ストレス / 病原性

Outline of Final Research Achievements

We analyzed the two-component regulatory systems that function by forming networks to sense the environmental stresses in Streptococcus pyogenes. Our analyses suggested that several sensor proteins are involved in sensing acid and also in oxidative stress and biofilm formation. We have found novel isolates that are considered to gain more virulence-associated factors by the analysis of one sensor protein. In addition we confirmed that CovS sensor protein plays important roles that S. pyogenes invades to aseptic tissues from septic tissues by the analysis of the several isolates from a single streptococcal-toxic-shock-syndrome patient.

Free Research Field

細菌学