2014 Fiscal Year Final Research Report
Study on the chronic inflammation and cell growth transformation induced by gammaherpesvirus infection
| Project/Area Number |
24590550
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
YASUI Teruhito 大阪大学, 微生物病研究所, 准教授 (60283074)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | Epstein-Barrウイルス / ウイルス発がん / Latent membrane protein / B細胞 / リンパ腫 / ノックインマウス / 持続感染 / 自己免疫疾患 |
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| Outline of Final Research Achievements |
Epstein-Barr virus (EBV) infects into the 90 % of human being in the world-wide and is thought to a causative agent for some malignancies. Of the EBV-coding genes, Latent membrane protein (LMP) has been known to be involved in the tumorigenesis. Here this study demonstrates that molecular pathogenesis by which both LMP1 and LMP2a expression in B cells gives rise to lymphomagenesis. Depletion of T cells resulted in the development of splenomegaly induced by aberrant B cell growth. In conclusion, this study clearly indicates that T cells is responsible for the regulation of EBV-induced cell growth transformation in vivo.
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| Free Research Field |
ウイルス学
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