Primate model and pathological analysis for Chikungunya virus infection

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590564
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: TAKASAKI Tomohiko 国立感染症研究所, その他部局等, その他 (20221351)
• Co-Investigator(Kenkyū-buntansha): MATSUTANI Ryuji 独立行政法人国立病院機構相模原病院, 臨床研究センター, 研究員 (70372290) ; SUZUKI Ryuji 独立行政法人国立病院機構相模原病院, 臨床研究センター, 室長 (70373470)
• Research Collaborator: NAKAYAMA Eri 国立感染症研究所, ウイルス第一部, 研究員 (40645339)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: チクングニアウイルス / マーモセット / 関節炎 / 肝機能障害 / 免疫不全マウス / ウイルス遺伝子

Outline of Final Research Achievements

Chikungunya virus is transmitted by Aedes albopictus same as dengue viruses. Marmoset could be infected with chikungunya virus and showed viremia and liver dysfunction. The viremia levels were enough to evaluate vaccine candidates and anti chikungunya viral drugs. Liver dysfunction were observed and viral antigens were identified in kupper cells of marmosets infected with chikungunya viruses. However any arthritis were not observed in the marmosets. We confirmed IFNaRI knock out mice infected with chikungunya viruses were shown arthritis. Genetically modified animals might be necessary to occur arthritis same as human chikungunya fever.

Free Research Field

ウイルス学