Research for genetic specificity of the Multi Drug-resistant Mycobacterium tuberculosis Spreading in Osaka Prefecture.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590651
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical sociology
• Research Institution: Osaka Prefectural Institute of Public Health
• Principal Investigator: TAMARU Aki 大阪府立公衆衛生研究所, その他部局等, 主任研究員 (70270767)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Soukichi 新潟大学, 医学部細菌学教室, 教授 (30244073) ; WADA Takayuki 長崎大学, 熱帯医学研究所, 助教 (70332450)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 多剤耐性結核菌 / 遺伝子型別 / ゲノム解析 / SNP解析

Outline of Final Research Achievements

V02 strain: the spreading multi drug-resistant Mycobacterium tuberculosis stain in Osaka Prefecture, were subjected to genome-wide analysis by next-generation sequencing. Compared with H37Rv, 1,445 SNPs were common to all 15 isolates belonging to V02 strain. Although 51 SNPs were found among 15 isolates of V02 strain, and V02 strains were divided into two groups by two SNPs (A to C at 7582 and G to A at 3157508). These results shows the existence of V02 strains was not from one outbreak causing by one infectious source but the isolates of V02 may have common ancestor.

Free Research Field

細菌学