What factors affect the ethnicity in drug response?: East Asian collaborative study

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590661
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Oita University
• Principal Investigator: KOTEGAWA Tsutomu 大分大学, 医学部, 准教授 (20264343)
• Co-Investigator(Renkei-kenkyūsha): OHASHI Kyoichi 大分大学, 副学長 (20137714) ; IMAI Hiromitsu 大分大学, 医学部, 准教授 (30398250) ; TSUTSUMI Kimiko 大分大学, 医学部, 助教 (20244171) ; OHYAMA Tetsuji 大分大学, 医学部, 助教 (60574085)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 医薬品応答性 / 東アジア / 民族差 / 遺伝子多型 / 外的要因

Outline of Final Research Achievements

The aim of this study is to elucidate the effect of the genetic variations (intrinsic factor) of drug transporters, and the effect of food/drink (extrinsic factor) on drug disposition and response in Japanese, Korean and Chinese population. The results showed a marked effect of food/drink as compared to genetic variations. In addition, ethnic differences, which are difficult to be explained by genetic variations, were found. Further studies regarding extrinsic factors in relation to drug disposition and response are necessary.

Free Research Field

臨床薬理学