2015 Fiscal Year Final Research Report
Development of a novel assay for prediction of response to anti-EGFR antibody therapy in colorectal cancer
| Project/Area Number |
24590674
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 分子標的治療 / 治療抵抗性 / コンパニオン診断 |
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| Outline of Final Research Achievements |
In this study, we attempted to develop a novel method to predict response to anti-EGFR therapy in colorectal cancer. A sensitive EGFR detection method using cetuximab and the simplified surrogate method were successfully established. However, these methods failed to enrich any responders to the therapy in RAS/BRAF wild-type colorectal cancer. We therefore explored novel predictive markers for the therapy by a comprehensive analysis of two different cell lines, KRAS wild-type and mutant, and identified twelve genes that changed between these cells. It is suggested that these candidate genes including a membrane protein related to nucleic acid metabolism might be predictive markers of anti-EGFR therapy.
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| Free Research Field |
医歯薬学
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