Microbiological and molecular epidemiological analyses of community-associated methicillin-resistant Staphylococcus aureus in Japan

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590676
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Nara Medical University (2014); Tohoku University (2012-2013)
• Principal Investigator: YANO Hisakazu 奈良県立医科大学, 医学部, 教授 (20374944)
• Co-Investigator(Kenkyū-buntansha): KUNISHIMA Hiroyuki 聖マリアンナ医科大学, 医学部, 准教授 (60339843)
• Research Collaborator: INOMATA Shinya
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: MRSA / CA-MRSA

Outline of Final Research Achievements

In this study, the MRSA isolates were classified as CA-MRSA or hospital-associated (HA)-MRSA according to a clinical classification based on patient information and a molecular classification based on SCCmec typing. Additionally, we performed PFGE and MLST.
Of the 231 MRSA isolates, 28 and 78 were classified as CA-MRSA by the clinical and molecular classifications, respectively. The most frequently detected CA-MRSA clone was sequence type 5-SCCmec IV, which has not previously been reported in Japan. The numbers of detected CA-MRSA isolates differed between the molecular classification and the clinical classification and the CA-MRSA detection frequency and the presence of the ST5-SCCmec IV clone were distinctive features in Japan.

Free Research Field

薬剤耐性菌