2014 Fiscal Year Final Research Report
Profile analysis of disease-related markers in synovial tissues of rheumatoid arthritis using imaging mass spectrometry
| Project/Area Number |
24590714
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Toyofumi 大阪医科大学, 医学部, 准教授 (10247843)
MAKINO Shigeki 大阪医科大学, 医学部, 教授 (20268204)
KOTANI Takuya 大阪医科大学, 医学部, 助教 (80411362)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 関節リウマチ / プロテオミクス |
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| Outline of Final Research Achievements |
This paper showed that the infiltration of inflammatory cells such as macrophages and lymphocytes into synovitis lesions and the expression of TGF-β, VEGF, MMP-3 and -9 in arthritis-model mice are elevated in comparison to control mice. Proteomics-based quantitative analysis showed the elevated expression of α-enolase and other unidentified markers in synovial tissues of arthritis. Tissue sections for imaging mass spectrometry could not obtained by microtome because of bone tissues and small samples.
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| Free Research Field |
膠原病
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