Hypogastric afferent cause hyperactive bladder following pelvic organ inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Akita University
• Principal Investigator: KAWATANI MASAHITO 秋田大学, 医学(系)研究科(研究院), 教授 (00177700)
• Co-Investigator(Kenkyū-buntansha): MIYAI Kazumasa 関西看護医療大学, 特任准教授 (60283933) ; ITO Tomoko 秋田大学, 大学院医学系研究科, 教授 (50241675) ; YOSHIZUMI Masaru 秋田大学, 大学院医学系研究科, 助教 (70553379)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 下腹神経 / 骨盤痛 / 過活動膀胱 / ATP / プロスタグランジン

Outline of Final Research Achievements

Afferent components of hypogastric nerve which innervate to urinary bladder, uterus or colon, modulate synaptic transmission of the hypogastiric ganglia in the cat. Storage of the urine in the bladder activate the afferent nerve activity and inhibit the sympathetic efferent activity. Inflammation of the uterus elicits the hypogastric nerve afferent activity and inhibit ten storage mechanisms to the bladder. This might one of the mechanism of the hyperactive bladder.

Free Research Field

自律神経科学、生理学、神経生理学