The roles of glycoprotein non-metastatic melanoma B (Gpnmb) in the modulation of ion channel activities and pain conduction

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590724
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Kanazawa University
• Principal Investigator: SHIGERU Yokoyama 金沢大学, 子どものこころの発達研究センター, 特任教授 (00210633)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Hiroaki 金沢大学, 保健管理センター, 教授 (10272981)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 痛み / 神経損傷 / Gpnmb

Outline of Final Research Achievements

The expression of glycoprotein non-metastatic melanoma B (Gpnmb) was up-regulated in both sciatic nerve and spinal cord injuries. In the lesioned sites, Gpnmb-immunoreactive cells were co-stained with markers including OX-42, ED1, and OX6. These results suggest that Gpnmb, which is produced by macrophages and microglia, may play important roles in pathophysiological processes in both peripheral and central nerve injuries.

Free Research Field

分子神経生物学