2014 Fiscal Year Final Research Report
Visualization of neural circuits for pain processing using genetically engineered mice
| Project/Area Number |
24590736
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Seiji 関西医科大学, 医学部, 教授 (80201325)
MATSUMURA Shinji 関西医科大学, 医学部, 講師 (70276393)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | カルシウムイメージング / 脊髄後角 / 体性感覚 |
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| Outline of Final Research Achievements |
To gain insight of how cutaneous sensory stimulation is processed and trasmitted to the brain, the present study focused on the establishment of in vivo calcium imaging of a large ensemble of neurons in the spinal dorsal horn critical for transmission of sensory information. This study revealed that cutaneous pinch, brush, and heat stimulation, and stimulation to different skin points triggered neuronal activities of different subsets of neurons. This result suggests that each subset of spinal dorsal horn neurons is involved in neuronal processing of different types of sensory stimulation.
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| Free Research Field |
神経科学
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