TGF-beta1 is associated with the progression of intracranial deep white matter lesions: a pilot study with 5 years of MRI evaluation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590809
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KURIYAMA Nagato 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60405264)
• Co-Investigator(Kenkyū-buntansha): WATANABE Yoshiyuki 京都府立医科大学, 大学院医学研究科, 教授 (00191809) ; OZAKI Etsuko 京都府立医科大学, 大学院医学研究科, 助教 (00438219)
• Co-Investigator(Renkei-kenkyūsha): MIZUNO Toshiki 京都府立医科大学, 大学院医学研究科, 教授 (30264782) ; YAMADA Kei 京都府立医科大学, 大学院医学研究科, 教授 (80315960)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: TGF-beta1 / サイトカイン / 脳内深部白質病変 / 慢性炎症

Outline of Final Research Achievements

Elevated expression of transforming growth factor (TGF)-beta1 has been reported in hereditary cerebral small-vessel (HCSV) disease. The aim of this study was to clarify whether TGF-beta1 is a risk factor for intracranial deep white matter lesions (DWLs) and their progression(progression of DWL) (DWLP)in a general elderly population.The subjects included 81 participants with brain MRI in 2003 and 2008.The highest TGF-beta1 levels were found in Group DWLP.The TGF-beta1 levels were significantly higher in Group DWLP than in Group DWL, and DWLP was ｓignificantly correlated with elevated TGF-beta1 levels (odds ratio: 1.72). Chronic kidbey disease might be involved in the pathogenesis of progression of DWLs and elevated TGF-β1. Our data suggest that TGF-beta1 is expected to be useful as a clinical indicator reflecting the presence ofintracranial white matter lesions or concomitant vascular cognitive decline.

Free Research Field

成人保健、社会医学