Studies on the characteristics and implications of CKD signs in cigarette smokers

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590821
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kanazawa Medical University
• Principal Investigator: NOBORISAKA Yuka 金沢医科大学, 医学部, 講師 (90288275)
• Co-Investigator(Kenkyū-buntansha): TABATA Masaji 金沢医科大学, 医学部, 非常勤講師 (40188404) ; MIYAO Masaru 名古屋大学, 情報科学研究科, 教授 (70157593)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Yuichi 金沢医科大学, 医学部, 教授 (70158228) ; ISHIZAKI Masao 金沢医科大学, 医学部, 准教授 (10184516) ; HONDA Ryumon 金沢医科大学, 看護学部, 教授 (60097441) ; YOKOYAMA Hitoshi 金沢医科大学, 医学部, 教授 (50191531)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 慢性腎疾患 / 喫煙 / 高血圧 / 血清γGT / HOMA-IR / 高感度CRP

Outline of Final Research Achievements

Serum creatinine (Cr) and cystatin C (Cys) were measured in the general middle-aged men, and estimated GFR (eGFRcr and eGFRcys) were compared. The mean of eGFRcr was higher in smokers than in non-smokers and the vice versa for eGFRcys. The high eGFRcr in smokers must be the reflection of low serum Cr in them but not truly elevated GFR. Smokers showing CKD had a higher blood pressure and serum γGT. The role of oxidative stress due to smoking in those associations should be further investigated.

Free Research Field

医歯薬学