Development of a method for analyzing aristolochic acid in crude drugs and kampo products.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590838
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Osaka Prefectural Institute of Public Health
• Principal Investigator: TAKAOMI Tagami 大阪府立公衆衛生研究所, 衛生化学部, 主任研究員 (00321943)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Akihiro 大阪府立公衆衛生研究所, 衛生化学部, 技師 (00622755)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 生薬 / アリストロキア酸

Outline of Final Research Achievements

In the analysis of aristolochic acid in the crude drug using the official method, it is sometimes difficult to judge existence or non-existence of aristolochic acid because of interfering peaks.
In this study, we investigated to develop a sensitive and selective method to analyze aristolochic acid. As a result, a selective method to analyze aristolochic acid in crude drugs and kampo products was established by the combination use of solid-phase extraction and high-performance liquid chromatography/ mass spectrometer.

Free Research Field

分析化学