Lifestyle factors on preventing oxidized LDL-cholesterol in urban residents

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590844
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Hyogo Medical University (2014); Foundation for Biomedical Research and Innovation (2012-2013)
• Principal Investigator: KUBOTA Yoshimi 兵庫医科大学, 医学部, 助教 (60403317)
• Co-Investigator(Renkei-kenkyūsha): OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567) ; HIGASHIYAMA Aya 国立循環器病研究センター, 研究開発基盤センター, 室長 (20533003) ; KADOTA Aya 滋賀医科大学, アジア疫学研究センター, 特任准教授 (60546068)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 疫学調査 / 動脈硬化予防 / LDL酸化 / 都市部住民 / 農村部住民

Outline of Final Research Achievements

In the Kobe study, the cohort study of urban residents, we measured serum tocopherols as a dietary factor. We reported in the academic conference that suggested that dietary vitamin E may be associated with lower oxidized low-density lipoprotein (Ox-LDL) and suppression of endothelial dysfunction. Other reports in the academic conferences were: the salt intake, taste recognition of salt and blood pressure; Ox-LDL and overweight or obesity. Furthermore, the original article was accepted for publication in J Nutr Health Aging. We examined the association between serum polyunsaturated fatty acids (as dietary factor) and systemic inflammation (Ox-LDL is known to be involved in) in the article. In the Sasayama study, the cohort study of rural residents, we measured Ox-LDL and urinary L-FABP (it is associated with oxidative stress and microvascular angiopathy). We also surveyed detail lifestyle factors in the Sasayama study and continuously progress the research findings.

Free Research Field

栄養疫学