2014 Fiscal Year Final Research Report
Application of messenger RNA expression of Chromogranin A to a biological marker for the suicide/non-suicide discrimination
| Project/Area Number |
24590857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | クロモグラニンA / 精神ストレス / RT-PCR |
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| Outline of Final Research Achievements |
We investigated whether the expression of messenger RNA (mRNA) of the chromogranin A (CgA) protein, which is a high sensitive marker of the psychological stress, improve precision of the suicide/non-suicide discrimination. No significant expression of CgA mRNA in pituitary gland, adrenal gland and submandibular gland of rats (12-38 weeks) after water-immersion restraint were observed. In the autopsy cases (62 cases), expression of CgA mRNA in pituitary gland (p<0.01) and adrenal gland (p<0.05) in suicide victims was significantly higher than in non-suicide victims. Higher expression of CgA mRNA in pituitary gland or adrenal gland in suicide victims may suggest the psychological stress with intentions to commit suicide.
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| Free Research Field |
法医学
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