2014 Fiscal Year Final Research Report
Mechanism of aversion to carbohydrate in citrin deficiency
| Project/Area Number |
24590892
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine (including Psychosomatic medicine)
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
USHIKAI Miharu 鹿児島大学, 医歯(薬)学総合研究科, 助教 (70232816)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKEYORI Saheki 熊本大学, 生命資源研究・支援センター, 特任教授 (10056070)
AKIHIRO Asakawa 鹿児島大学, 医歯学総合研究科, 准教授 (10452947)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | シトリン欠損症 / 食行動解析 |
|---|
| Outline of Final Research Achievements |
In this research, we analyzed the mechanism of aversion to carbohydrate in citrin deficiency using a model mouse. Our analysis on the appetite-related neuropeptides revealed a higher expression of urocortin1 (Ucn1) in the model mouse under the fed conditions.Oral sucrose administration significantly increased blood lactate concentration in the model mouse as compared with the wild-type, suggesting that the increases in blood lactate and Ucn1 expression in the central nervous system are related to the aversion in the model mouse.
|
| Free Research Field |
健康科学 栄養学
|
