Study of the molecular mechanism underlying genomic alterations during Helicobacter pylori-associated gastric carcinogenesis.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590915
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: MATSUMOTO Yuko 京都大学, 医学(系)研究科(研究院), 助教 (20452360)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ヘリコバクター・ピロリ / 胃癌 / ゲノム異常

Outline of Final Research Achievements

With persistent infection of Helicobacter pylori (H. pylori), gastric cancer develops by a multistep process occurring through the accumulation of genetic alterations in gastric epithelial cells. The mechanisms how the gastric epithelial cells with H. pylori infection and the resultant inflammatory response acquire the genetic changes leading to malignant transformation, however, remain unknown. Activation-induced cytidine deaminase (AID) induces somatic mutations in various host genes, and we demonstrated that H. pylori infection induced aberrant AID expression in gastric epithelial cells.
We plan to investigate the role of AID in the occurrence of genetic alterations, including genetic and epigenetic changes. We clarify the overall genetic alterations induced by aberrant AID activity using the next generation sequencing. A successful outcome of this research project would provide the novel insight into the molecular mechanisms of infection- and inflammation-associated carcinogenesis.

Free Research Field

医学