CD66a-mediated crosstalk between intestinal epithelia and lymphocytes

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590936
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NAGAISHI Takashi 東京医科歯科大学, 医学部附属病院, 助教 (60447464)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Tetsuya 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 (70265809) ; WATANABE Mamoru 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
• Research Collaborator: YAMAZAKI Motomi ; ONIZAWA Michio ; SUZUKI Masahiro ; WATABE Taro ; HOSOYA Akinori ; JOSE Nisha ; WANG Shuan ; TOKAI Arisa ; TSUGE Naoto ; KAWAI Risa
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 炎症性腸疾患 / 粘膜免疫 / クロストーク / サイトカイン / CD66a

Outline of Final Research Achievements

Inflammatory Bowel Disease (IBD) is characterized by unrestrained lymphocyte activation that results in the production of a variety of pro-inflammatory cytokines and other mediators. Understanding the mechanisms of lymphocyte regulation is therefore of significant importance to dysregulated mucosal inflammation such as IBD. An area that is of significant interest is the cell autonomous mechanisms of T cell regulation through proteins that have natural inhibitory functions when expressed on T lymphocytes. In this regard, we have observed that CD66a has the general property of negatively regulating T cell responses initiated by antigen presentation. Defining the mechanisms of CD66a-mediated T cell regulation will lead to a significant understanding of the manner in which manipulation of this molecule may provide insights into novel therapeutic methods for the treatment of IBD.

Free Research Field

消化器内科学