2014 Fiscal Year Final Research Report
Mucosal IgG plasma cell as a novel therapeutic target in the pathogenesis of ulcerative colitis .
| Project/Area Number |
24590951
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOKUTAKE Mina 慶應義塾大学, 医学部, 研究員 (30468524)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 潰瘍性大腸炎 / IgG産生形質細胞 / ケモカイン受容体 / 免疫複合体 |
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| Outline of Final Research Achievements |
Chronic inflammation characterized by IgG-producing plasma cell infiltration of colonic mucosa is a histological hallmark of ulcerative colitis (UC).IgG plasma cells that were markedly increased in number in the inflamed mucosa of UC patients showed a distinct expression profile (CCR10 low /CXCR4 high) compared with IgA plasma cells (CCR10 high/CXCR4 low).IgG-immunocomplex(IC) stimulation activated intestinal CD14+ macrophages that were increased in number in the inflamed mucosa of UC patients via FcgR, and induced the extensive production of pro-inflammatory cytokines. IgG-IC may promote inflammatory response in CD14+ macrophages independent from signaling pathway in bacteria stimulation. IgG-IC signaling via FcgR and IgG plasma cell could be novel therapeutic targets for UC.
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| Free Research Field |
消化器内科学。特に炎症性腸疾患の病態解明と治療。粘膜免疫学
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