The analysis of the function and the clinical application of REIC/Dkk-3 gene in digestive organ cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590977
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Okayama University
• Principal Investigator: KATO Hironari 岡山大学, 大学病院, 助教 (60619039)
• Co-Investigator(Kenkyū-buntansha): TSUTSUMI Koichiro 岡山大学, 岡山大学病院, 助教 (40610910) ; SHIRAHA Hidenori 岡山大学, 岡山大学病院, 講師 (40379748) ; YAMAMOTO Kazuhide 岡山大学, 大学院医歯薬学総合研究科, 教授 (90140491) ; NASU Yasutomo 岡山大学, 岡山大学病院, 教授 (20237572)
• Research Collaborator: UCHIDA Daisuke 岡山大学, 岡山大学病院, 医員 (50749215)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: REIC/Dkk-3 / 膵臓癌 / 遺伝子治療 / 癌抑制遺伝子

Outline of Final Research Achievements

REIC/Dkk-3, tumor suppressor gene, is down-regulated in various malignant tumors. In the current study, we assessed the effects of REIC/Dkk-3 gene therapy in pancreatic cancer. The REIC/Dkk-3 expression was lost in the pancreatic cancer cells, and tissues. Overexpression of REIC/Dkk-3 induced the apoptosis of the pancreatic cancer cells and inhibited tumor growth in xenograft mice model. REIC/Dkk-3 gene therapy is an attractive therapeutic tool for the pancreatic cancer.

Free Research Field

消化器内科