Role of B cell activating factor in the pathogenesis of NAFLD

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590979
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: ABE MASANORI 愛媛大学, 医学(系)研究科(研究院), 准教授 (40432786)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アディポカイン / 脂肪肝 / インスリン抵抗性

Outline of Final Research Achievements

In this study, we analyzed the role of B cell activating factor (BAFF), which is one of the adipokines, in the pathogenesis of fatty liver diseases, especially in visceral adipose tissue and liver. We found that oxidative stress induced BAFF expression in adipocytes, and BAFF led to impaired insulin sensitivity in visceral adipose tissue. On the other hand, BAFF had a protective role in hepatic steatosis by regulating lipid metabolism in the liver. These data indicate that the role of BAFF in the liver may differ from that in visceral adipose tissue in the pathogenesis of fatty liver diseases.

Free Research Field

肝臓病学