The role of PKR and its modification to the function of host cell in hepatocellular carcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590980
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: HIASA Yoichi 愛媛大学, 医学(系)研究科(研究院), 教授 (70314961)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PKR / 肝細胞癌 / 細胞増殖 / C型肝炎ウイルス / MAPK / c-Jun / c-Fos / JNK

Outline of Final Research Achievements

We previously reported that protein kinase RNA-depended (PKR) is overexpressed in hepatocellular carcinoma (HCC) with hepatitis C virus (HCV) infection, as compared with surrounding non-HCC tissues. Cell proliferation significantly increased by PKR expression, moreover that was dependent on PKR-modulated c-Fos and c-Jun expression in the HCV-replicating cell lines. We also confirmed the coordinate expression of c-Fos and c-Jun with PKR in human HCC specimens. These findings suggest that the overexpressed PKR would some roles for proliferation of HCC, and could be one of the targeted molecules to treat the HCC related with HCV.

Free Research Field

医歯薬学