Clarify the molecular mechanism of acute pancreatitis and develop a new approach for treatment of pancreatitis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Akita University
• Principal Investigator: MASHIMA Hirosato 秋田大学, 医学(系)研究科(研究院), 講師 (10261869)
• Co-Investigator(Kenkyū-buntansha): OHNISHI Hirohide 秋田大学, 大学院医学系研究科, 教授 (00313023)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 膵炎 / 膵外分泌 / S100g / Anxa10

Outline of Final Research Achievements

The mechanism of the onset of acute pancreatitis is still unknown. There has been no progress in the treatment of acute pancreatitis. The pancreas of interferon regulatory factor-2 (IRF-2) knock-out mice shows the early phase of acute pancreatitis (Mashima H et al. Gastroenterology 2011). We have selected candidate genes of acute pancreatitis among the highly up-regulated or down-regulated genes in IRF2 KO pancreas compared to the control. Finally, we have chosen the two genes, which are both calcium-binding proteins. Then, we analyzed the function of S100g and Anxa10 by using a cell line, which is manipulated genetically, and wild-type and knock-out mice. We have shown S100g may have an important role in the onset of acute pancreatitis.

Free Research Field

消化器内科学、膵臓病学