2014 Fiscal Year Final Research Report
Elucidation of the biological function of non-coding repeat RNA in pancreatic cancer using mouse models
| Project/Area Number |
24591005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Motoyuki 東京大学, 医学部附属病院消化器内科, 助教 (90518945)
IJICHI Hideaki 東京大学, 医学部附属病院消化器内科, 助教 (70463841)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 膵癌 / 非コードRNA |
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| Outline of Final Research Achievements |
Repeat RNA, one of the non-coding RNAs which express in pancreatic cancer tissues, is expressed exclusively in the cancerous tissues. Its expression was not detected in the normal pancreas tissues. Thus, we hypothesized that this repeat RNA may be involved in the parthenogenesis of the pancreatic cancer. To clarify this, we constructed onverexpression system of this repeat RNA in culture cells. We observed deregulated chromatin division and impaired repair of the damaged DNA in cells, which may contribute to the malignant phenotype of cancer cells.
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| Free Research Field |
消化器内科学
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